Tuberculosis(寃고��, ���濡�, ��몄��)

���. ������

쨌 a chronic infectious disease caused by mycobacteria of tuberculosis complex, mainly mycobacterium tuberculosis
쨌 ��뱀��
1. Granuloma formation with intense tissue inflam. and damage

2. Cell-mediated hypersensitivity

3. Prolonged latency period

쨌 usual site : Lung (85-89%)
���. Incidence
��곕━ ������ ��щ�������� 8��� (`91)
寃고�듯�������� 45��щ��紐�
38.8% (17留�紐�) : 寃고�듯�����濡� 移�猷�
61.2% (28留�紐�) : 蹂몄�몄�� 寃고�듯����������� 紐⑤Ⅴ硫� ��⑥��寃� ������ 以�
寃고�듭�ㅽ��
95������ 珥�寃고�듯����� 43留�紐�, ��멸뎄 (100紐���� 1紐�(1%))
援���� 寃고�� ��щ����� 3,700 (10留�紐���� 7.4紐�) , ��щ�������� 10���
��������� - ��⑥�� 64% < 40��� / ��ъ�� 75% < 30���
���. Etiology
Tuberculosis Complex
M. tuberculosis
M. bovis
M. africanum
Mycobacteria cell walls ��� rich in lipids or waxes
Doubling time : 18 hrs
An obligate aerobe, facultative intracellular parasite

���. Pathogenesis

Primary infection
(primary lesion - Non-specific pneumonitis in middle or lower lu���(������)