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¼¼Æ÷ÁÖ±â¿Í ¾ÆÆ÷Åä½Ã½º (Cell Cycle and Apoptosis)

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¼¼Æ÷ÁÖ±âÀÇ Á¶Àý°ú ¾ÆÆ÷Åä½Ã½º(Apoptosis)¿¡ ´ëÇÑ ³»¿ëÀ» Á¤¸®ÇÑ ÀÚ·áÀÔ´Ï´Ù. °ü·Ã º¸°í¼­¸¦ ÀÛ¼ºÇϽ÷Á´Â ºÐµé¿¡°Ô ¸ðÂÉ·Ï µµ¿òÀÌ ÀÖÀ¸¸®¶ó »ý°¢ÇÕ´Ï´Ù. ¸ðµÎ ÁÁÀº °á°ú ¹ÞÀ¸½Ã±æ ¹Ù¶ø´Ï´Ù.
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I. ¼¼Æ÷ÁÖ±âÀÇ Á¶Àý

1. ¼­·Ð

2. ¼¼Æ÷ÁÖ±â ÀÎÀÚ

1) CDC À¯ÀüÀÚ

2) Cyclin-Dependent Protein Kinases(CDKs) ¹× Cyclins

3. ¼¼Æ÷ÁÖ±âÀÇ Á¶Àý

1) G1/S phase

2) G2/M phase

3) CDKÀÇ Á¶Àý

4. Restriction point Á¶Àý°ú ¾Ï

II. Apoptosis
1. ¼­·Ð
2. ApoptosisÀÇ ÇüÅÂÇÐÀû ¹× »ýÈ­ÇÐÀû º¯È­
3. Apoptosis¿¡ °ü°èÇÏ´Â À¯ÀüÀÚ
4. Á¤»óÀûÀÎ ¹ß´Þ¿¡ À־ ApoptosisÀÇ ¿ªÇÒ

5. ¾Ï¿¡¼­ÀÇ Apoptosis

º»¹®/³»¿ë

ÀÌ¿Í °°ÀÌ G2 phase¿¡¼­ M phase·Î ³Ñ¾î¿Â ¼¼Æ÷´Â ¼¼Æ÷Áú ºÐ¿­(cytokinesis)ÀÌ ÀϾ¸é¼­ ¼¼Æ÷º®ÀÌ Çü¼ºµÇ°í, ½ÇÁ¦ ÇÑ °³ÀÇ ¼¼Æ÷°¡ µÎ °³ÀÇ ¼¼Æ÷·Î ³ª´µ¾îÁö°Ô µÈ´Ù. ÀÌ·¯ÇÑ À¯»çºÐ¿­ÀÇ °úÁ¤Àº ¿ªµ¿ÀûÀÎ °úÁ¤À̳ª ¼³¸íÀ» À§ÇÏ¿© Àü±â(prophase), Áß±â(metaphase), Èıâ(anaphase), Á¾±â(telophase)·Î ¼¼ºÐÇÏ°í ÀÖ´Ù.(±×¸² 1)

2. ¼¼Æ÷ÁÖ±â ÀÎÀÚ

1) CDC À¯ÀüÀÚ

¼¼Æ÷ÁÖ±â´Â ¸ðµç ÁøÇÙ¼¼Æ÷¿¡¼­ °øÅëÀ¸·Î G1, S, G2, M phase¸¦ °ÅÃÄ ÀϾ´Âµ¥, ¼¼Æ÷ÀÇ Á¾·ù¿¡ µû¶ó °¢ phase¸¦ °ÅÄ¡´Â ½Ã°£Àº Â÷ÀÌ°¡ ÀÖ´Ù. S ¹× M phase¿¡¼­ ¼¼Æ÷Áֱ⸦ °üÀåÇÏ´Â ÁÖÀÛ¿ëÀÌ ÀϾÁö¸¸ G1 ¹× G2 phase´Â ¼¼Æ÷ÁÖ±âÀÇ ÁøÇà¿©ºÎ¸¦ Á¡°ËÇÏ´Â ½Ã±â¶ó°í ÇÒ ¼ö ÀÖ´Ù.
ÀÌ·¯ÇÑ ¼¼Æ÷ÁÖ±âÀÇ °¢ phase¿¡´Â À̸¦ ÁÖ°üÇÏ´Â °ü·ÃÀÎÀÚµéÀÌ ÀÖÀ¸¸ç, À̵鿡 ÀÇÇÏ¿© ¼¼Æ÷ÁÖ±âÀÇ ÁøÇàÀÌ Á¶ÀýµÈ´Ù. ´ëÇ¥ÀûÀ¸·Î ¾Ë·ÁÁø ¼¼Æ÷ÁÖ±â ÀÎÀڷδ CDC(Cell Division Cycle) À¯ÀüÀÚ°¡ ÀÖÀ¸¸ç, ¶ÇÇÑ cyclin°ú °°Àº ÀÎÀÚµéÀÌ ¼¼Æ÷ÁÖ±â, ƯÈ÷ G1, G2 phase¿¡¼­, CDC À¯ÀüÀÚµé°ú »óÈ£ÀÛ¿ë Çϸ鼭 ¼¼Æ÷Áֱ⸦ Á¶ÀýÇÏ´Â ¹°Áú·Î ¹àÇôÁ® ÀÖ´Ù.(±×¸² 2)
CDC À¯ÀüÀÚ´Â È¿¸ð¿Í °°Àº ´Ü¼ø ÁøÇÙ¼¼Æ÷¿¡¼­´Â À¯ÀüÇÐÀû ºÐ¼®ÀÌ ½¬¾î ¾à¡¦(»ý·«)
Âü°í¹®Çå

1. O`Farrell PH: Cell cycle control: Many ways to skin a cat. Trends Cell Biol 2:159, 1992.
2. MitChison JM: The Biology of Cell Cycle. New York: Cambridge University Press, 1971.
3. Hartwell LH, Weinert TA: Checkpoints: Controls that ensure the order of cell cycle events. Science 246:629, 1989.
4. Nurse P, Bisset Y: Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature 292:558, 1981.
5. Beach DH, Durkacz B, Nurse P: Functionally homologous cell cycle control genes in budding and fission yeast. Nature 300:706, 1982.
6. Murray AW, Kirschner MW: Dominoes and clocks: The union of two views of the cell cycle. Science 246:614, 1989.
7. Lee MC, Nurse P: Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. Nature 327:31, 1987.
8. Pines J: Cyclins: Wheels within wheels. Cell Growth Diff 2:305, 1991.
9. Kirschner M: The cell cycle then and now. Trends Biochem Sci 17:281, 1992.
10. Evans T, Rosenthal ET, Youngblom J, Distel D, Hunt T: Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 33:389, 1983.
11. Pardee AB: G1 events and regulation of cell proliferation. Science 246:603, 1989.
12. DeBondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH: Crystal sructure of cyclin-dependent kinase 2. Nature 363:595, 1993...


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¼¼Æ÷ÁÖ±â   ¾ÆÆ÷Åä½Ã½º   Cell   Cycle   Apoptosis  


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