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Pathophysiology and therapy of pruritus in allergic and
atopic diseases
J. Buddenkotte1 & M. Steinhoff2
1Deparment of Dermatology, Boltzmann Institute for Cell- and Immunobiology of the Skin, University Hospital Mu¨ nster, Mu¨ nster, Germany;
2Depatments of Dermatology and Surgery, University of California, San Francisco, CA, USA
(1)Deparment of Dermatology, Boltzmann Institute for Cell- and Immunobiology of the Skin, University Hospital Mu¨ nster, Mu¨ nster, Germany;
(2)Depatments of Dermatology and Surgery, University of California, San Francisco, CA, USA
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Itch transmission by the nervous system
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The skin barrier
protect from the outside
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Pruritus
An unpleasant sensation
to scratch
constitutes an essential
feature of atopic dermatitis
low-intensity pain
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Pruritus
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P…(생략)
NK-1 RECEPTOR
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o the superfamily of transient receptor potential(TRP) channels.
To date, six groups of molecules complete this superfamily: the anonical (TRPC), the melastatin (TRPM), the polycystin (TRPP), the ankyrin transmembrane protein 1 (TRPA), the mucolipin (TRPML) and the vanilloid (TRPV) subfamilies.
Only recently, functional TRPV1 channels were reported on numerous nonneuronal cell types, including human epidermal and hair follicle keratinocytes, endothelial cells, dermal mast cells and dendritic cells.
itching sensitization might also be related to the activation of other TRPs expressed in the skin, sensory fibres and keratinocytes including TRPV2, TRPV3, TRPV4, TRPA1 and TRPM8(Fig. 2).
In fact, an important role for TRPV3 in pruritus has been shown recently.
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Figure 2.
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Cannabinoids
Another suspect in the itch department is the cannabinoid system. Cannabinoid receptor-1 (CB1) is co-localized with TRPV1 in sensory neurons and cannabinoids interact w
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