나노소재설계-Nanoparticle Layer Nanochip (LSPR)

Multiple Label-Free Detection of Antigen-Antibody Reaction Using Localized Surface Plasmon Resonance-Based Core-Shell Structured Nanoparticle Layer Nanochip
2007.10.22. Mo, Na Ae
Lee, So Hee
Heo, Ji Ho
Sung, Gyung Jin
Tatsuro Endo, Kagan Kerman, Naoki Nagatani, Ha Minh Hiepa, Do-Kyun Kim, Yuji Yonezawa, Koichi Nakano, and Eiichi Tamiya
Anal. Chem. 2006, 78, 6465-6475
Department of Machano-Micro Engineering, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, 226-8502, Japan
Introduction
LSPR-Based NanoChip을 이용한 단백질의 Detection

Post-Genome 시대의 도래
- Proteomics의 시대
- great scale + fast + high senstivity 〓 anal system 요망
-] 소형화, Multidetection

지금까지 개발된 MEMS,NEMS 를 이용한 바이오센서
-] LABELING 필요 (단점)
-] LSPR을 이용한 Detection

Materials & Apparatus
Experimental

4,4’-Dithiodibutyric acid (DDA)
1-Ethyl-3’-(3-dimethylaminop…(생략)